Write-up by hi joiney
In the colorful life of the world, what causes the diversity of life developing appealing? Soon after years of painstaking research professor at Nanjing University boldly created "Indel mutation hypothesis", with the newly discovered "universal mechanism of genetic mutation," cracked the biology of several suspense. July 20, the latest issue of "Nature" magazine published in Nanjing University to total this independent investigation.In the "natural" "published in eukaryotes insertion / deletion mutations increase the rate of the surrounding sequences," the paper, College of Life Science, Nanjing University, Professor Tian Dacheng, Chen and other independent groups and several drafts to total wisdom.Considering that 2005, their bio-informatics technology by human, chimpanzee, rhesus monkeys, mice, fruit flies, such as rice and distinct kinds of yeast genome sequences were compared to the analysis. Investigation found, DNA insertion / deletion (Indel) will trigger a series of variations around. On this basis, they proposed "Indel mechanism of spontaneous mutation induction hypothesis", the success from the source to answer the "how the genetic variation of the formation of" the fundamental issues facing the life sciences. The hypothesis that the genome of diverse species can be utilised for reference frame to be tested, and received the support of a variety of test results.Tian Dacheng explained that the mutations primarily refers to the nucleotide sequence of DNA, kind and quantity of alter, and DNA sequence widespread point (bp) mutation is the fundamental source of genetic variation. Point mutations are divided into spontaneous mutation and induced mutation. For a lengthy time, the academic program of the classical understanding of spontaneous mutation is spontaneous mutations by a quantity of aspects, the result is a series of modifications, with the randomness and rarity. But as the last century because the 90's DNA sequencing technology breakthrough, the researchers of the spontaneous mutations in the genome with the number and distribution of accurate estimates, and normally considered the "spontaneous mutations in the genome are not randomly distributed, the mutation Hot widespread in the genome. " This conclusion of the spontaneous mutation of conventional understanding of randomness and rarity, tremendous challenge, and this phenomenon has caused great concern amongst scientists, but sadly has not found a general mechanism to explain this major scientific questions.Tian Dacheng and other genetic mutations discovered a new mechanism is of excellent scientific significance, successfully cracked a lot of suspense on biological genetics: first, all regions of the genome mutation rate is really various, the number of spontaneous mutation is the quantity and density of the Indel decision, the number of spontaneous mutations are not rare in Indel near, far away from Indel region is rare, but Indel itself is a point mutation, its occurrence has some randomness, so the induced mutations also have a particular randomness Second, find the source of the majority of spontaneous mutation, ie, biological diversity, the initial source of variation is mainly induced by the Indel Third, natural selection to a huge extent by the option of the Indel implementation The level of spontaneous mutation rate is largely the result of natural selection Fourth, biological variation via the ability to regulate their own capacity to adapt to the environment than people originally expected, although, that the role of mutations in evolution enormous.The outcomes not only lead to a significant number of scientific issues, also has prospective applications, such as the somatic cells of the Indel mutation effects may be the key to unlock the mechanism of tumor huge Indel overall mutation effects, understanding the origin of life play an important role Indel amplification mutation heterozygote effect, the mutation rate can considerably enhance the genetic breeding of crops have substantial potential value.
About the Author
The e-commerce company in China delivers top quality items such as Mud Pump, Geological Drilling Rig , and far more. For more, please visit core drilling today!
Comments :
0 comments to “Chinese scientists have found genetic mutation common mechanism - Mud Pump - Geological Drilling Rig”
Post a Comment